No problem

Don't take my word as a plan though

How many do you expect daily? Do you know/use any load testing tools?
Would you like to set up a sample page with some features on your server to test both CMS and server? How many pages do you estimate to load in CMS?
Did you prepare a list of features that can invalidate the cache? It often is set to bust after info is saved to database (counting page-hits with cms, voting, polls, comments, uploaded posts, user-registration, admin saving data in backend, search with cache off etc). Couch is better than many other CMSs, but every chicken needs a good recipy